Technology
STEP1
Sample Pre
STEP2
Automation
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STEP3
LC-MS/MS
STEP4
Data Services
Nano-Architected Hierarchical Design
Monodisperse magnetic nanoparticles with tightly controlled size (particle-to-particle uniformity) ensure stability and lot-to-lot consistency in complex sample matrices.
AI-Guided Ligand Selection
Surface ligands are screened and optimized by AI/ML to achieve high target specificity, enabling precise nanoscale biointeractions to recognize and capture low-abundance proteins.
High Affinity & Selectivity
Selective binding drives formation of a dense, target-specific protein corona on the nanoparticle surface, markedly increasing capture efficiency while suppressing nonspecific adsorption—enhancing analytical sensitivity and accuracy.
Integrated, end-to-end automation
Covers the entire pre–mass spectrometry sample-prep workflow, enabling true load-and-go operation.
Modular design, flexible fit
Accommodates diverse sample types—such as plasma, urine, and cell-culture supernatant—and scales seamlessly to different throughput needs.
Enabling diverse research applications
Delivers high-quality, reproducible proteomics data to power disease-mechanism studies, drug target discovery, and biomarker screening.
Free your hands, focus on innovation
Our automated platform reduces manual error and boosts efficiency and process control, so your team can spend more time on discovery
Integrated, end-to-end automation
Covers the entire pre–mass spectrometry sample-prep workflow, enabling true load-and-go operation.
Modular design, flexible fit
Accommodates diverse sample types—such as plasma, urine, and cell-culture supernatant—and scales seamlessly to different throughput needs.
Enabling diverse research applications
Delivers high-quality, reproducible proteomics data to power disease-mechanism studies, drug target discovery, and biomarker screening.
Free your hands, focus on innovation
Our automated platform reduces manual error and boosts efficiency and process control, so your team can spend more time on discovery.
Peptide generation and ionization
Proteins are enzymatically digested into peptides and ionized by electrospray ionization (ESI) to produce charged ions.
m/z window segmentation
The predefined m/z range (e.g., 400–1,200) is partitioned into multiple small isolation windows (e.g., 25 Da each).
Parallel fragmentation and acquisition
All ions within each window are fragmented simultaneously, yielding complex multiplexed MS/MS spectra.
Spectral-library matching and analysis
Identifications and quantitative readouts are obtained by matching observed spectra to an empirical or predicted spectral library.
Raw Data Processing
Format conversion and QC filtering.
Protein Identification
Database searching (e.g., DIA-NN, Spectronaut).
Differential Analysis
Identify significantly altered proteins.
Visualizations: volcano plots, heatmaps, principal component analysis (PCA).
Functional Annotation & Pathway Analysis
Gene Ontology (GO) categorization—Molecular Function, Biological Process, Cellular Component—and KEGG pathway enrichment analysis.
Proteonano™ UltraPlex Proteomics Platform
The Proteonano™ Ultraplex Proteomics Platform, developed by Nanomics Biotechnology, is a highly automated and standardized system. It consists of the Proteonano™ Kit, Nanomics G1 workstation, and AI-powered proteomics analysis software, specifically addressing the bottlenecks in detecting low-abundance proteins in mass spectrometry-based proteomics.
Proteonano™ Kit series is composed of AI-designed polypeptides to selectively bind and enrich low abundant proteins in biofluid samples with picogram sensitivity and peptide-level specificity.
Features
Multiplex + Ultradepth
Detect 1,000-5,000 plasma proteins and biomarkers in a single run, spanning 9 orders of magnitude in abundance.
Unbiased Detection
Provides broad analysis of the entire proteome, including post-translational modifications, allelic variations, and alternative splicing.
High Throughput
Greatly simplify sample prep, allowing the workstation to process 100 samples per day per unit.
Seamless Integration
Seamlessly fits into existing LC-MS workflows, compatible with various LC-MS, and requires no extra large equipment.
